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High above the Earth, Top Gun pilot turned astronaut Frank White commands his first Space Shuttle mission. While in orbit, the science team runs a critical experiment utilizing the unique properties of micro-gravity to cultivate a weaponized strain of the Ebola virus. Back on Earth, an accident on the way to de-brief leaves all but one of the entire science team dead. Suspecting foul play, Frank White infiltrates the hospital where Dr. Bender is quarantined, and learns that the accident was arranged, and the Ebola in the experimental container had been stolen. Frank takes this information to James Kelly, the Deputy Director of Intelligence for the CIA. Immediately after, Frank is nearly killed on a training flight when his unarmed FA-18 is attacked by a mysterious F-15. Frank and former SEAL team leader Bone Conn uncover a plot to turn the Ebola virus into a weapon of mass destruction. Lives hang in the balance as the two men and their team of Navy SEALS become locked in a black op to stop the ultimate terrorist attack.